2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (294):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-168662
    Palbociclib-CH2COOH 2139329-57-8
    Palbociclib-CH2COOH is a Ligands for Target Protein for PROTACs. Palbociclib-CH2COOH can serve as an active control for the target protein ligand of CPD-39 (HY-168664) and CPD-10 (HY-168660).
    Palbociclib-CH2COOH
  • HY-158340
    TYK2 ligand 1 2770471-05-9
    TYK2 ligand 1 is a TYK2 ligand in the synthesis of PROTAC-based TYK2 degrader (CPD-155, HY-158142).
    TYK2 ligand 1
  • HY-163610
    AKR1C3-IN-13
    AKR1C3-IN-13 (Compound 4) is an AKR1C3 inhibitor. AKR1C3-IN-13 degrades AKR1C3 in prostate cancer cells.
    AKR1C3-IN-13
  • HY-44824
    SMARCA2 ligand-13 2660235-29-8
    SMARCA2 ligand-13 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMARCA2 ligand-13 can be used for synthesis PROTACs.
    SMARCA2 ligand-13
  • HY-173136
    KDM4 ligand-1
    KDM4 ligand-1 is a ligand for target protein (histone lysine demethylase KDM4) for PROTACs. KDM4 ligand-1 can be used in the synthesis of PROTACs (HY-173135).
    KDM4 ligand-1
  • HY-170339
    ER ligand-5 2421262-07-7
    ER ligand-5 is the ligand for estrogen receptor, that can be used as ligand for target protein for PROTAC synthesis of PROTAC ERα Degrader-10 (HY-170336).
    ER ligand-5
  • HY-111849
    Imatinib carbaldehyde 1436868-85-7
    Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
    Imatinib carbaldehyde
  • HY-170349
    SMARCA2 ligand-11 3033592-44-5
    SMARCA2 ligand-11 is the ligand for SMARCA2, and can be used for synthesis of PROTAC SMARCA2 degrader-32 (HY-170343) as ligand for target protein.
    SMARCA2 ligand-11
  • HY-158771
    PRC1 ligand 1 2467965-59-7
    PRC1 ligand 1 is a target protein ligand of MS147 (HY-160924). PRC1 ligand 1 can be used to study cancer.
    PRC1 ligand 1
  • HY-170672
    XPO1-ligand-1
    XPO1-ligand-1 is a target protein ligand for XPO1 and can be used to synthesize PROTAC PROTAC XPO1 degrader-1 (HY-170669).
    XPO1-ligand-1
  • HY-170341
    ER ligand-6 2504914-79-6
    ER ligand-6 is a target protein ligand of PROTAC ER Degrader-14 (HY-170340).
    ER ligand-6
  • HY-158430
    CYP1B1 ligand 2 2836297-58-4
    CYP1B1 ligand 2 is a target protein ligand of PROTAC CYP1B1 degrader-2 (HY-158429). CYP1B1 ligand 2 can be used to study lung cancer.
    CYP1B1 ligand 2
  • HY-170330
    AR ligand-33
    AR ligand-33 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-8 (HY-170329) as the target protein ligand.
    AR ligand-33
  • HY-145484
    PROTAC IRAK4 ligand-3 2434848-46-9
    PROTAC IRAK4 ligand-3 is a ligand of PROTAC KT-474 (HY-145483) that can be used in cancer research.
    PROTAC IRAK4 ligand-3
  • HY-163963
    IBT6A-CO-ethyne 1970122-88-3
    IBT6A-CO-ethyne is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). IBT6A-CO-ethyne can be used for synthesis IBT6A (HY-13036A).
    IBT6A-CO-ethyne
  • HY-170450
    AR ligand-38
    AR ligand-38 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-9 (HY-170448).
    AR ligand-38
  • HY-170860
    CK1δ/CK1ε liagnd-1
    CK1δ/CK1ε liagnd-1 is the ligand for CK1δ/CK1ε that can be used for synthesis of CK1 PROTAC degrader AH078 (HY-170859) as the ligand for target protein.
    CK1δ/CK1ε liagnd-1
  • HY-168287
    HDAC3/8 ligand-1
    HDAC3/8 ligand-1 (compound 40) is a ligand for target protein for PROTAC that can be used in the synthesis of YX968 (HY-164233).
    HDAC3/8 ligand-1
  • HY-162738
    JMV6944 2871774-93-3
    JMV6944 is a PXR agonist. JMV6944 competitively inhibits hPXR ligand-binding domain (LBD) binding to PXR with an IC50 of 680nM. JMV6944 induces CYP3A4 mRNA expression in freshly isolated human primary human hepatocyte cultures. JMV6944 can be used for the synthesis of PROTAC PXR degrader JMV7048 (HY-162704).
    JMV6944
  • HY-159573
    Napabucasin analogue 1133287-34-9
    Thalidomide acid is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Thalidomide acid can be used in synthesis Napabucasin (HY-13919).
    Napabucasin analogue